Granny is very old and when she tells stories of her young life sometimes, they can be a bit long, gross, or boring (especially to Jimmy).
Granny is said to be over 60 years old. She has light Grey hair fone up into a bun and wears glasses. She bares a strong resemblance to her son, Hugh. She wears a Green long sleeve dress with White lace and Black heels with White stockings.
As a baby, she is bald except for a Brown curl on top of her head. She has big Brown eyes and one bottom tooth. She wears only a diaper.
In her first appearance in "Granny Baby," Jimmy accidentally turned her into a baby. It was hard to handle her like that considering that she had just pooped in her diaper. She ended up pooping herself a couple more times and it just kept getting worse until Jimmy got Cindy to change the diaper. When she was a baby Granny apparently had a pooping problem as she always pooped in her diaper. Not too long after her dirty diaper was changed and she later asked for another. While she could still talk and use big words, her mind was immature and it made her act like a regular baby.
"Send in the Clones"
"Clash of the Cousins"
While not actually appearing, Granny has been mentioned as being in Reno at the time of the party.
- Granny Neutron wasn't the only Nicktoons character Phyllis Diller did the voice for, as she previously voiced Aunt Mitzi on Hey Arnold!