Team Nick is a team of crime-fighting heroes from the Nicktoons multiverse led by Jimmy Neutron. The group often teams up to solve problems that are usually caused in the multiverse.
- Jimmy Neutron - A teenage boy genius, who lives in Retroville and often researches the many Earths in the multiverse. He is the leader and the brains of the group.
- Timmy Turner - A ten year old average kid, who no one understands. He has two fairies named Cosmo and Wanda and has teamed up with Jimmy several times. He is the clown of the team.
- Danny Phantom - A half-ghost human hybrid who lives in Amity Park. He is the brawn of the group.
- SpongeBob SquarePants - An anthropomorphic sea sponge, who lives in the underwater city of Bikini Bottom. He is the team mascot.
- Sam Manson - Danny's goth girlfriend, who is a firm believer in everything she preaches.
- Tucker Foley - Danny's best buddy, who is a computer geek and provides reliable sources with his techno gadgets.
- Goddard - Jimmy's robot dog and lab assistant.
- Patrick Star - An anthropmorphic starfish, who is SpongeBob's best friend.
- Tak - A tribal boy from the Pupu Nunu people, who practices magic called Juju.
- Aang - An airbending boy from the Four Nations, who is the last member of his race.
- Zim - An Irken invader, who is plotting to take over the world.
- Cosmo and Wanda - Timmys fairy godparents.